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Nov - Sohrab Shah

Speaker: Sohrab Shah

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Talk Title: Mutation discovery in cancer using next generation sequencing and probabilistic models

Event Details

Date/Time:

November 26, 2009, 6:00pm **PLEASE NOTE THE DATE CHANGE**

Molecular Oncology Department, BC Cancer Agency

URL:
Sohrab Shah

Abstract:

The advent of next generation sequencing (NGS) has propelled the field of cancer

genomics forward such that it is now cost-effective to interrogate entire genomes or

transcriptomes of clinical tumor samples for the presence of somatic mutations: often

the key driver genomic alterations in tumorigenesis. Since the number of data points

produced by NGS experiments is in the billions, variant discovery is necessarily a

computational exercise. I will describe the development of novel computational methods

for the discovery of mutations from NGS, based on probabilistic models. I will present

results of applying these approaches in two recent studies in ovarian and breast cancer:

namely the discovery of a novel recurrent and defining mutation in the FOXL2 gene in

granulosa cell tumours of the ovary and the first description of mutational evolution of a

breast cancer seen at nucleotide resolution.

Presentation:
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Introductory Speaker:
Hye-Jung Elizabeth Chun, MSc Candidate

**Talk Title:**     
Gene expression of breast tumors with different responses to immunotherapy


**Affiliation:**     
[Bioinformatics Graduate Program, UBC](http://www.bioinformatics.ubc.ca/)


**Presentation:**     
[Download Presentation:material-file-powerpoint-box:](https://drive.google.com/file/d/1IBCp5KH_9GBtA_1l9MCVSW9RVyMLfc8c/view?usp=sharing)


### The upcoming 2009-2010 meeting dates


December 10, 2009 Main Speaker: TBD; Intro Speaker: Rodrigo Goya, Marra Lab, Genome Sciences Centre, BCCA


January 13, 2010  **\*\*PLEASE NOTE THE DATE CHANGE\*\*** Main Speaker:  [Evan Eichler](http://eichlerlab.gs.washington.edu/) , University of Washington; Intro Speaker: TBD


March 11, 2010 Main Speaker:  [Rich Bonneau](http://homepages.nyu.edu/~rb133/) , New York University; Intro Speaker: TBD


April 8, 2010 Main Speaker:  [Joerg Gsponer](http://www.chibi.ubc.ca/faculty/gsponer) , Centre for High-Throughput Biology; Intro Speaker: Kieran O’Neill, Brinkman Lab, BCCRC