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Nov - Sohrab Shah

Speaker: Sohrab Shah

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Talk Title: Mutation discovery in cancer using next generation sequencing and probabilistic models

Event Details


November 26, 2009, 6:00pm **PLEASE NOTE THE DATE CHANGE**

Molecular Oncology Department, BC Cancer Agency

Sohrab Shah


The advent of next generation sequencing (NGS) has propelled the field of cancer

genomics forward such that it is now cost-effective to interrogate entire genomes or

transcriptomes of clinical tumor samples for the presence of somatic mutations: often

the key driver genomic alterations in tumorigenesis. Since the number of data points

produced by NGS experiments is in the billions, variant discovery is necessarily a

computational exercise. I will describe the development of novel computational methods

for the discovery of mutations from NGS, based on probabilistic models. I will present

results of applying these approaches in two recent studies in ovarian and breast cancer:

namely the discovery of a novel recurrent and defining mutation in the FOXL2 gene in

granulosa cell tumours of the ovary and the first description of mutational evolution of a

breast cancer seen at nucleotide resolution.

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Introductory Speaker:
Hye-Jung Elizabeth Chun, MSc Candidate

**Talk Title:**     
Gene expression of breast tumors with different responses to immunotherapy

[Bioinformatics Graduate Program, UBC](

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### The upcoming 2009-2010 meeting dates

December 10, 2009 Main Speaker: TBD; Intro Speaker: Rodrigo Goya, Marra Lab, Genome Sciences Centre, BCCA

January 13, 2010  **\*\*PLEASE NOTE THE DATE CHANGE\*\*** Main Speaker:  [Evan Eichler]( , University of Washington; Intro Speaker: TBD

March 11, 2010 Main Speaker:  [Rich Bonneau]( , New York University; Intro Speaker: TBD

April 8, 2010 Main Speaker:  [Joerg Gsponer]( , Centre for High-Throughput Biology; Intro Speaker: Kieran O’Neill, Brinkman Lab, BCCRC