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Vancouver Bioinformatics Users Group

VanBUG (Vancouver Bioinformatics Users Group) is an association of researchers, other professionals and students in the B.C. Lower Mainland who have an interest in the field of bioinformatics.

VanBUG meets on the second Thursday of every month from September through April. Research presentations by bioinformatics leaders, students and industry representatives are followed by networking over pizza and refreshments

Meetings are held in the Gordon and Leslie Diamond Family Theatre, BC Cancer Research Centre, 675 West 10th Avenue at 6:00 pm and are free and open to all.

As a service to the community, other bioinformatics events are posted to the Calendar
Visit our sister groups for bioinformatics events in Montreal (MonBUG) and now Toronto (TorBUG)!

next speakers:

Amee Manges

Talk Title:
Investigations into the microbiome and chronic childhood undernutrition

Wednesday, October 12, 2016 6:00pm

Associate Professor, University of British Columbia

Web-site: Amee Manges
Twitter: @amee_manges

Chronic malnutrition, termed stunting, is defined as suboptimal linear growth, affects one third of children in developing countries, and leads to increased mortality and poor developmental outcomes. Recent studies have shown that the intestinal microbiota can induce changes in weight; however, no studies have investigated the gut microbiota as a determinant of chronic malnutrition or stunting. We performed secondary analyses of data from two well-characterized twin cohorts of children from Malawi and Bangladesh to identify bacterial genera associated with linear growth. In a case-control analysis, we used the graphical lasso to estimate covariance network models of gut microbial interactions from relative genus abundances and used network analysis methods to select genera associated with stunting severity. In longitudinal analyses, we determined associations between these selected microbes and linear growth using between-within twin regression models to adjust for confounding and introduce temporality. Reduced microbiota diversity and increased covariance network density were associated with stunting severity, while increased relative abundance of Acidaminococcus sp. was associated with future linear growth deficits.

Amee Manges is a molecular epidemiologist and Associate Professor at the School of Population and Public Health and supervises a research laboratory at BCCDC. She received her PhD in epidemiology from the University of California at Berkeley. Her interests are in human microbiome research and the application of next-generation sequencing tools to infectious disease epidemiology.

Ethan Gough is a Post-doctoral Fellow at the University of British Columbia working with Dr. Amee Manges. He is an epidemiologist who utilizes “-omics” data and bioinformatic tools in the context of epidemiologic studies to investigate the role of the gut microbiome in global health challenges, such as childhood undernutrition and enteric infections.

Please note:
Trainees are invited to meet with the VanBUG speaker for open discussion of both science and career paths. This takes place 5:00-5:45pm in either the Boardroom or Lunchroom on the ground floor of the BCCRC

Recommended Readings


Introductory Speaker:
Eric Zhao (MD/PhD student, Dr. Steven Jones’ lab, BC Genome Sciences Centre)

“Unraveling the cancer genome’s geological record”


Webcast Link:
(This technology is brought to you by Compute Canada and WestGrid with support from PHSA Telehealth)

To view previous VanBUG posters and presentations, please see Archives

sponsored by:

CIHR Bioinformatics Training Program

Canadian Bioinformatics Workshops

Genome BC

Proof Centre

past sponsors:


Creative Commons License
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