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 Sohrab Shah

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Talk Title:
Mutation discovery in cancer using next generation sequencing and probabilistic models

November 26, 2009, 6:00pm **PLEASE NOTE THE DATE CHANGE**

Molecular Oncology Department, BC Cancer Agency

Sohrab Shah

The advent of next generation sequencing (NGS) has propelled the field of cancer
genomics forward such that it is now cost-effective to interrogate entire genomes or
transcriptomes of clinical tumor samples for the presence of somatic mutations: often
the key driver genomic alterations in tumorigenesis. Since the number of data points
produced by NGS experiments is in the billions, variant discovery is necessarily a
computational exercise. I will describe the development of novel computational methods
for the discovery of mutations from NGS, based on probabilistic models. I will present
results of applying these approaches in two recent studies in ovarian and breast cancer:
namely the discovery of a novel recurrent and defining mutation in the FOXL2 gene in
granulosa cell tumours of the ovary and the first description of mutational evolution of a
breast cancer seen at nucleotide resolution.

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Introductory Speaker:
Hye-Jung Elizabeth Chun, MSc Candidate

Talk Title:
Gene expression of breast tumors with different responses to immunotherapy

Bioinformatics Graduate Program, UBC

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The upcoming 2009-2010 meeting dates

December 10, 2009 Main Speaker: TBD; Intro Speaker: Rodrigo Goya, Marra Lab, Genome Sciences Centre, BCCA

January 13, 2010 **PLEASE NOTE THE DATE CHANGE** Main Speaker: Evan Eichler , University of Washington; Intro Speaker: TBD

March 11, 2010 Main Speaker: Rich Bonneau , New York University; Intro Speaker: TBD

April 8, 2010 Main Speaker: Joerg Gsponer , Centre for High-Throughput Biology; Intro Speaker: Kieran O’Neill, Brinkman Lab, BCCRC