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 Olga Troyanskaya

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Talk Title:
Digging in data: how computation can be used to drive biological discovery

March 12, 2009, 6:00pm

Princeton University, Lewis-Sigler Institute for Integrative Genomics

Olga Troyanskaya

The explosion of functional genomics data, including microarray,
proteomics, and high-throughput genetic studies, has the promise of a
systems-level view of protein function, interactions, and regulation.
In the future, such systems-level understanding of biology can pave
the way for predictive physiological models and molecular medicine.
However, these data are noisy, computationally diverse, and
biologically heterogeneous. I will discuss our recent work in
developing robust methods for integrated analysis of these data with
the goal of enabling exploration and discovery of novel biology, and
in addressing the disconnect between computation and experiments
through an integrative computational-experimental framework for
function discovery. We applied these methods to data from human and
model organisms, identifying and experimentally validating previously
unknown protein functions, including several new players in
macroautophagy in human fibroblasts and over 100 new mitochondrial
organization and biogenesis proteins in yeast.

VanBUG is pleased to welcome CSCBC 2009 delegates
For more information on the CSCBC Conference:

Introductory Speaker:

Monica Sleumer

Talk Title:
De Novo Detection of Regulatory Elements in C. elegans

Jones Laboratory, Genome Sciences Centre