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 Hamid Bolouri

Talk Title:
Decompostion of large-scale genetic regulatory networks into functional building blocks

September 14, 2006, 6pm

Currently at the Institute for Systems Biology, Seattle
Moving in October to the Centre for Molecular Medicine & Therapeutics,

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The availability of a large number of annotated genomes has shown that
metazoan complexity arises primarily from more complex regulatory
interactions among genes and their products. At the same time, high
throughput technologies are delineating the location, abundance, state,
and interactions of genes and their products with increasing resolution
in terms of cell types, time points and conditions. A recent phenomenon
accompanying the reconstruction of large-scale molecular interaction
maps is the publication of often unfathomably large network diagrams.
For such figures to be comprehensible, it is necessary to superimpose
one or more layers of functional abstraction on top of the low-level
interactions that comprise these very complex networks. Using examples
from my group’s work, I will outline some limitations of existing
approaches to network decomposition and argue that we need to start at
the bottom, by characterizing the features necessary to impose a unique
function to building blocks of one or few genes. From these, a
hierarchical library of functional sub-system archetypes underlying all
GRNs may be constructed. I will present a few examples such “functional
building blocks”.

Student Speaker:
William Hsiao, Molecular Biology and Biochemistry, Simon Fraser
University (F. Brinkman lab)

Talk title:
Genomic island analysis: Improved software and insights into an apparent
gene pool associated with genomic islands.

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